Professor In Residence
+1 415 502-7998
EDUCATION
College: Harvard University, AB
Medical/Graduate School: University of California, San Francisco, MD, PhD
RESEARCH
My current research areas of interest focus on the predictive and pathogenetic role of biomarkers for both acute and chronic disease states. My long term goal is to identify and validate novel biomarkers of organ injury (specifically, the kidney and lung) that may have predictive value for disease outcomes as well as shed important insight into disease pathogenesis. In addition, I have a major interest in clinical trials in the Intensive Care Unit, with a particular focus on acute lung injury and acute kidney injury.
Publications
Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit.
Annals of the American Thoracic Society
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Cytometry masked autoencoder: An accurate and interpretable automated immunophenotyper.
Cell reports. Medicine
Addressing Inpatient Hyponatremia Through Targeted Automatic E-consults: A Pilot Randomized Trial.
Journal of general internal medicine
Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement.
Intensive care medicine
Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials.
Intensive care medicine
Acute Kidney Injury and Subsequent Cardiovascular Disease: Epidemiology, Pathophysiology, and Treatment.
Seminars in nephrology
Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.
CHEST critical care
Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.
Critical care (London, England)
Rapidly improving ARDS differs clinically and biologically from persistent ARDS.
Critical care (London, England)
Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock.
Journal of the American College of Emergency Physicians open
Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL).
Intensive care medicine
Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
American journal of respiratory and critical care medicine
Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.
American journal of respiratory and critical care medicine
Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials.
Critical care (London, England)
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.
Critical care (London, England)
Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL).
Intensive care medicine
A New Global Definition of Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.
Intensive care medicine
The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events.
Kidney international
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
The Lancet. Respiratory medicine
Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study.
Annals of internal medicine
Subgroups of patients with distinct health utility profiles following acute kidney injury.
Kidney360
Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
Critical care (London, England)
Probing the association between AKI and cardiovascular outcomes.
Clinical journal of the American Society of Nephrology : CJASN
Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes: The ASSESS-AKI Study.
Clinical journal of the American Society of Nephrology : CJASN
Care of the Hospitalized Patients with Kidney Failure during COVID-19 Pandemic: Lessons Learned.
Clinical journal of the American Society of Nephrology : CJASN
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
The New England journal of medicine
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
American journal of physiology. Lung cellular and molecular physiology
Intraoperative Use of Albumin in Major non-cardiac surgery: Incidence, Variability, and Association with Outcomes.
Annals of surgery
Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial.
Critical care (London, England)
Overview of the Medical Management of the Critically Ill Patient.
Clinical journal of the American Society of Nephrology : CJASN
Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
Nature microbiology
Informed consent process in the ISPY COVID trial is ethically acceptable.
European journal of internal medicine
The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.
Critical care (London, England)
Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
Journal of the Endocrine Society
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Critical care (London, England)
Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study.
BMC nephrology
Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Subphenotypes in acute kidney injury: a narrative review.
Critical care (London, England)
Optimizing the Design and Analysis of Future AKI Trials.
Journal of the American Society of Nephrology : JASN
Factors associated with risk and prognosis of intensive care unit admission in patients with acute leukemia: a Danish nationwide cohort study.
Leukemia & lymphoma
Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy.
Clinical journal of the American Society of Nephrology : CJASN
Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
American journal of respiratory and critical care medicine
Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury.
Kidney international reports
Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study.
Journal of the American Society of Nephrology : JASN
Introduction to Critical Care Nephrology and Acute Kidney Injury.
Clinical journal of the American Society of Nephrology : CJASN
Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
Shock (Augusta, Ga.)
Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events After Acute Kidney Injury.
Journal of the American Society of Nephrology : JASN
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
The Lancet. Respiratory medicine
Kidney Dysfunction After Acute Heart Failure: Is Acute Kidney Disease the New Acute Kidney Injury?
Kidney international reports
Healthy versus inflamed lung environments differentially effect MSCs.
The European respiratory journal
Preface.
Critical care clinics
Recovery after Critical Illness and Acute Kidney Injury.
Clinical journal of the American Society of Nephrology : CJASN
Identifying the Sickest During Triage: Using Point-of-Care Severity Scores to Predict Prognosis in Emergency Department Patients With Suspected Sepsis.
Journal of hospital medicine
Achieved blood pressure post-acute kidney injury and risk of adverse outcomes after AKI: A prospective parallel cohort study.
BMC nephrology
Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
Critical care explorations
Association Between Kidney Dysfunction Types and Mortality Among Hospitalized Patients with Cirrhosis.
Digestive diseases and sciences
Kidney Replacement Therapy in the ICU: Less Is More (Death)?
American journal of kidney diseases : the official journal of the National Kidney Foundation
Pathophysiology of COVID-19-associated acute kidney injury.
Nature reviews. Nephrology
Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Changes in intensive care unit admission rates, organ support, and mortality in patients with acute myeloid leukaemia over a 12-year period: a Danish nationwide cohort study.
British journal of haematology
Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative.
Nature reviews. Nephrology
Outpatient Dietary Management of Electrolyte Disorders During COVID-19: Food as Medicine.
JAMA internal medicine
Biomarkers of inflammation and repair in kidney disease progression.
The Journal of clinical investigation
Survey of Current Practices of Outpatient Hemodialysis for AKI Patients.
Kidney international reports
A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis.
American journal of physiology. Lung cellular and molecular physiology
Prospective Cohort Study of Renin-Angiotensin System Blocker Usage after Hospitalized Acute Kidney Injury.
Clinical journal of the American Society of Nephrology : CJASN
Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains.
Critical care medicine
Biological Mechanisms of COVID-19 ARDS.
American journal of respiratory and critical care medicine
Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
Nature reviews. Nephrology
Alternative Tobacco Product Use in Critically Ill Patients.
International journal of environmental research and public health
The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.
Transplantation
AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.
Journal of the American Society of Nephrology : JASN
COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
Nature reviews. Nephrology
Using Best Subsets Regression to Identify Clinical Characteristics and Biomarkers Associated with Sepsis-Associated Acute Kidney Injury.
American journal of physiology. Renal physiology
Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia.
American journal of respiratory and critical care medicine
Improving Care for Patients after Hospitalization with Acute Kidney Injury.
Journal of the American Society of Nephrology : JASN
Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
American journal of physiology. Lung cellular and molecular physiology
Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury.
Kidney diseases (Basel, Switzerland)
Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.
Pediatric pulmonology
Recovery of Kidney Function Among Patients With Glomerular Disease Starting Maintenance Dialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions.
Kidney international reports
A prospective cohort study that examined acute kidney injury and kidney outcomes, cardiovascular events and death informs on long-term clinical outcomes.
Kidney international
Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.
BMC nephrology
Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.
The New England journal of medicine
Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy.
Critical care (London, England)
Renin-angiotensin system blockers and 1-year mortality in patients with post-operative acute kidney injury.
Acta anaesthesiologica Scandinavica
Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
Critical care medicine
The attributable mortality of acute respiratory distress syndrome.
Intensive care medicine
Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
Kidney international
AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI.
Clinical journal of the American Society of Nephrology : CJASN
Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes.
JAMA network open
Gender Differences in Authorship of Critical Care Literature.
American journal of respiratory and critical care medicine
Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
Intensive care medicine
Clinical Trials for AKI: Lessons Learned From the ARDS Network.
Seminars in nephrology
Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study.
JAMA internal medicine
Exciting developments in the field of acute kidney injury.
Nature reviews. Nephrology
Critical Care Nephrology: Core Curriculum 2020.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Peripheral Blood Leukocyte Telomere Length is Associated with Survival of Sepsis Patients.
The European respiratory journal
Renin-Angiotensin System Blockade after Acute Kidney Injury (AKI) and Risk of Recurrent AKI.
Clinical journal of the American Society of Nephrology : CJASN
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
Critical care (London, England)
Lung Inflammatory Environments Differentially Alter Mesenchymal Stromal Cell Behavior.
American journal of physiology. Lung cellular and molecular physiology
Association of Elevated Plasma Interleukin 18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome.
Critical care medicine
Impact of AKI on Urinary Protein Excretion: Analysis of Two Prospective Cohorts.
Journal of the American Society of Nephrology : JASN
Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study.
Clinical kidney journal
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
The New England journal of medicine
Quality Improvement Goals for Acute Kidney Injury.
Clinical journal of the American Society of Nephrology : CJASN
Identification of Acute Kidney Injury Sub-phenotypes with Differing Molecular Signatures and Response to Vasopressin Therapy.
American journal of respiratory and critical care medicine
Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
The Lancet. Respiratory medicine
Prediction Models for AKI: Will They Result in Improved Outcomes for AKI?
Clinical journal of the American Society of Nephrology : CJASN
Management of hyperkalemia in the acutely ill patient.
Annals of intensive care
Predicting Renal Recovery After Dialysis-Requiring Acute Kidney Injury.
Kidney international reports
Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
The Lancet. Respiratory medicine
Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.
Canadian journal of kidney health and disease
Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.
American journal of physiology. Lung cellular and molecular physiology
Biological Variability of Estimated GFR and Albuminuria in CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials.
Respiratory care
Selection of Intravenous Fluids.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study.
BMC nephrology
Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.
Journal of the American Heart Association
Remote organ failure in acute kidney injury.
Journal of the Formosan Medical Association = Taiwan yi zhi
Acute Kidney Injury and Risk of Heart Failure and Atherosclerotic Events.
Clinical journal of the American Society of Nephrology : CJASN
Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.
Annals of emergency medicine
Contrast-Induced Acute Kidney Injury in the PRESERVE Trial: Lessons Learned.
Clinical journal of the American Society of Nephrology : CJASN
Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.
Clinical journal of the American Society of Nephrology : CJASN
Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.
American journal of medical quality : the official journal of the American College of Medical Quality
Duration of acute kidney injury in critically ill patients.
Annals of intensive care
Management of Acute Kidney Injury: Core Curriculum 2018.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Pre-admission proteinuria impacts risk of non-recovery after dialysis-requiring acute kidney injury.
Kidney international
Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System.
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Acute Respiratory Distress Syndrome.
The New England journal of medicine
Pathophysiology of AKI.
Best practice & research. Clinical anaesthesiology
Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families.
Critical care medicine
Acute Kidney Injury Ascertainment Is Affected by the Use of First Inpatient Versus Outpatient Baseline Serum Creatinine.
Kidney international reports
Acute Respiratory Distress Syndrome.
The New England journal of medicine
No impact of surviving sepsis campaign care bundles in reducing sepsis-associated acute kidney injury?.
Clinical nephrology
Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.
Critical care medicine
AKI Adjudication: Do We Need It.
Nephron
What endpoints should not be used for clinical studies of acute kidney injury?
Intensive care medicine
The ten barriers for translation of animal data on AKI to the clinical setting.
Intensive care medicine
Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study.
Clinical journal of the American Society of Nephrology : CJASN
Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup.
Nature reviews. Nephrology
Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.
American journal of physiology. Lung cellular and molecular physiology
Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.
American journal of respiratory and critical care medicine
Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome.
Annals of the American Thoracic Society
Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.
Critical care (London, England)
Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.
Kidney international
Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.
The New England journal of medicine
Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
RRT in AKI: Start Early or Wait?
Clinical journal of the American Society of Nephrology : CJASN
Statistical Methods for Cohort Studies of CKD: Prediction Modeling.
Clinical journal of the American Society of Nephrology : CJASN
Does Changing the Volume Matter? The Relationship of Urine Volume and Dialysis Intensity.
Clinical journal of the American Society of Nephrology : CJASN
Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2*IGFBP7 biomarker study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
The acute respiratory distress syndrome following isolated severe traumatic brain injury.
The journal of trauma and acute care surgery
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
Critical care (London, England)
ATS Core Curriculum 2016: Part II. Adult Critical Care Medicine.
Annals of the American Thoracic Society
Changing Faces of Critical Care Nephrology.
Advances in chronic kidney disease
Critical Care Updates for the Nephrologist, 2016.
Advances in chronic kidney disease
Acute kidney injury: Clinical trials in AKI: is the end in sight?
Nature reviews. Nephrology
Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient.
Clinics in chest medicine
Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Bridging Translation by Improving Preclinical Study Design in AKI.
Journal of the American Society of Nephrology : JASN
Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial.
Journal of the American Society of Nephrology : JASN
The authors reply.
Critical care medicine
Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study.
Clinical journal of the American Society of Nephrology : CJASN
What a Nephrologist Needs to Know About Acute Liver Failure.
Advances in chronic kidney disease
Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup.
Critical care medicine
Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care.
Clinical journal of the American Society of Nephrology : CJASN
Promoting Kidney Function Recovery in Patients with AKI Requiring RRT.
Clinical journal of the American Society of Nephrology : CJASN
When change is not a good thing.
Clinical chemistry
Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.
Critical care medicine
Finding the key to dialysis catheter lock.
American journal of respiratory and critical care medicine
Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply.
The Lancet. Respiratory medicine
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
American journal of physiology. Lung cellular and molecular physiology
Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium.
Clinical journal of the American Society of Nephrology : CJASN
Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
Intensive care medicine
Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup.
Clinical toxicology (Philadelphia, Pa.)
Preparing for renal replacement therapy in patients with the Ebola virus disease.
Blood purification
Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
Intensive care medicine
Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.
Critical care medicine
Body temperature and mortality in patients with acute respiratory distress syndrome.
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
The Lancet. Respiratory medicine
Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Therapeutic strategies for clinical trials targeting renal recovery.
Nephron. Clinical practice
Rosuvastatin for sepsis-associated ARDS.
The New England journal of medicine
Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.
Critical care medicine
Propofol as a panacea for acute kidney injury?
Kidney international
Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
Annals of intensive care
Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
Journal of intensive care
Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
The New England journal of medicine
The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.
Journal of critical care
Cardiovascular events after AKI: a new dimension.
Journal of the American Society of Nephrology : JASN
Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significanc
The Journal of thoracic and cardiovascular surgery
Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth.
Current biology : CB
The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial.
Respiratory care
Evolving practices in critical care and their influence on acute kidney injury.
Current opinion in critical care
Urine stability studies for novel biomarkers of acute kidney injury.
American journal of kidney diseases : the official journal of the National Kidney Foundation
AKI: a path forward.
Clinical journal of the American Society of Nephrology : CJASN
The authors reply.
Kidney international
Acute kidney injury: an increasing global concern.
Lancet (London, England)
Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
American journal of respiratory and critical care medicine
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation.
Biomarker insights
Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease.
Kidney international
Critical care nephrology: update in critical care for the nephrologist.
Advances in chronic kidney disease
Fluid overload in AKI: epiphenomenon or putative effect on mortality?
Current opinion in critical care
Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.
American journal of physiology. Lung cellular and molecular physiology
Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup.
Clinical journal of the American Society of Nephrology : CJASN
The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology.
Clinical toxicology (Philadelphia, Pa.)
Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings.
Clinical journal of the American Society of Nephrology : CJASN
Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials.
Clinical journal of the American Society of Nephrology : CJASN
Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology.
Clinical journal of the American Society of Nephrology : CJASN
Ongoing clinical trials in AKI.
Clinical journal of the American Society of Nephrology : CJASN
Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes.
Critical care medicine
Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury.
American journal of respiratory and critical care medicine
The value of positive end-expiratory pressure and Fio2 criteria in the definition of the acute respiratory distress syndrome.
Critical care medicine
FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study.
Annals of intensive care
Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study.
Annals of intensive care
Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
Critical care research and practice
Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia.
American journal of respiratory and critical care medicine
Fluid balance, diuretic use, and mortality in acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN
Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Curbing the use of ultrasonography in the diagnosis of acute kidney injury: Penny wise or pound foolish?: Comment on "Renal ultrasonography in the evaluation of acute kidney injury".
Archives of internal medicine
Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.
Critical care medicine
The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.
BMC nephrology
Acute kidney injury: is acute kidney injury a risk factor for long-term mortality?
Nature reviews. Nephrology
Acute renal syndrome/renal angina: a new paradigm for studies of acute kidney injury?
Clinical journal of the American Society of Nephrology : CJASN
Clinical trials for acute kidney injury: design challenges and possible solutions.
Current drug targets
Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value.
American journal of physiology. Lung cellular and molecular physiology
Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study.
Critical care (London, England)
Inhaled activated protein C: a novel therapy for acute lung injury?
Critical care (London, England)
Protective mechanisms of activated protein C in severe inflammatory disorders.
British journal of pharmacology
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.
Pediatric pulmonology
Some methodological issues in studying the long-term renal sequelae of acute kidney injury.
Current opinion in nephrology and hypertension
Long-term outcomes after acute kidney injury: where we stand and how we can move forward.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Critical care nephrology: Core Curriculum 2009.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
American journal of physiology. Renal physiology
Impact of acute kidney injury on lung injury.
American journal of physiology. Lung cellular and molecular physiology
Randomized clinical trial of activated protein C for the treatment of acute lung injury.
American journal of respiratory and critical care medicine
Protein C as a surrogate end-point for clinical trials of sepsis.
Critical care (London, England)
Renal repair and recovery.
Critical care medicine
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
The Journal of biological chemistry
Diagnosis, epidemiology and outcomes of acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN
Advances in critical care for the nephrologist: acute lung injury/ARDS.
Clinical journal of the American Society of Nephrology : CJASN
Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.
Critical care medicine
Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
American journal of physiology. Renal physiology
The incidence and prognostic significance of acute kidney injury.
Current opinion in nephrology and hypertension
Timing of initiation of dialysis in critically ill patients with acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN
Evolving practices in critical care and potential implications for management of acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN
Formation of multicellular epithelial structures.
Novartis Foundation symposium
Management of acidosis during lung-protective ventilation in acute respiratory distress syndrome.
Respiratory care clinics of North America
Molecular mechanisms of recovery from acute renal failure.
Critical care medicine