Assistant Adjunct Professor
M_MED-CORE-PULM
+1 415 476-0735
My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.
Publications
E-cigarette exposure disrupts antitumor immunity and promotes metastasis.
Frontiers in immunology
Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance.
Critical care (London, England)
Neutrophil Reduction Attenuates the Severity of Lung Injury in the Early Phase of Pneumococcal Pneumonia in Mice.
American journal of physiology. Lung cellular and molecular physiology
A New Global Definition of Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
Frontiers in immunology
Impact of E-Cigarette Aerosol on Primary Human Alveolar Epithelial Type 2 Cells.
American journal of physiology. Lung cellular and molecular physiology
Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
American journal of respiratory and critical care medicine
Aerosolized Vitamin E Acetate Causes Oxidative Injury in Mice and in Alveolar Macrophages.
American journal of physiology. Lung cellular and molecular physiology
Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.
Physiological reports
Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis.
Journal of vascular surgery cases and innovative techniques
Inhibition of the Lipoxin A4 and Resolvin D1 Receptor Impairs Host Response to Acute Lung Injury Caused by Pneumococcal Pneumonia in Mice.
American journal of physiology. Lung cellular and molecular physiology
Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.
American journal of respiratory cell and molecular biology
THE EX-VIVO PERFUSED HUMAN LUNG IS RESISTANT TO INJURY BY HIGH-DOSE S. PNEUMONIAE BACTEREMIA.
American journal of physiology. Lung cellular and molecular physiology
Treatment for severe acute respiratory distress syndrome from COVID-19.
The Lancet. Respiratory medicine
What are the respiratory effects of e-cigarettes?
BMJ (Clinical research ed.)
Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice.
American journal of physiology. Lung cellular and molecular physiology
Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
The Lancet. Respiratory medicine
High Power Vaping Injures the Human Lung.
American journal of physiology. Lung cellular and molecular physiology
Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
The Lancet. Respiratory medicine
Possible hepatotoxicity of IQOS.
Tobacco control
Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
American journal of physiology. Lung cellular and molecular physiology
Cell-based Therapy in Sepsis. A Step Closer.
American journal of respiratory and critical care medicine
Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
American journal of physiology. Lung cellular and molecular physiology
Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
Nature cell biology
Pulmonary toxicity of e-cigarettes.
American journal of physiology. Lung cellular and molecular physiology
Persistent Pathology in Influenza-Infected Mouse Lungs.
American journal of respiratory cell and molecular biology
Sepsis: pathophysiology and clinical management.
BMJ (Clinical research ed.)
Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.
Clinics in chest medicine
Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.
American journal of physiology. Lung cellular and molecular physiology
Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
Annals of intensive care
Treating ARDS: new hope for a tough problem.
The Lancet. Respiratory medicine
Mesenchymal stem cells and the stem cell niche: a new chapter.
American journal of physiology. Lung cellular and molecular physiology
Mesenchymal stem cells and acute lung injury.
Critical care clinics
Mechanisms of subventricular zone expansion after focal cortical ischemic injury.
The Journal of comparative neurology
Vascular changes in the subventricular zone after distal cortical lesions.
Experimental neurology
Migration and fate of newly born cells after focal cortical ischemia in adult rats.
Journal of neuroscience research
Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy
Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane.
Journal of neurotrauma
Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction.
Proceedings of the National Academy of Sciences of the United States of America